Principal species threatened or in danger  of the Annex II of the Protocol concerning specially protected areas and biological diversity in the Mediterranean  :  Posidonia oceanica, Zostera marina, Zostera noltii, Cystoseira amentacea (including var. stricta and var. spicata), Goniolithon byssoides, Lithophyllum lichenoides, Aplysina sp. plur., Axinella polypoides, Ircinia foetida, Ircinia pipetta, Petrobiona massiliana, Tethya sp. plur., Gerardia savaglia, Asterina pancerii, Centrostephanus longispinus, Ophidiaster ophidianus, Charonia lampas (= Ch. rubicunda = Ch. nodifera), Dendropoma petraeum, Erosaria spurca, Lithophaga lithophaga, Luria lurida (= Cypraea lurida), Patella ferruginea, Pholas dactylus, Pinna nobilis, Ranella olearia (= Argobuccinum olearium = A. giganteum), Zonaria pyrum, Cetorhinus maximus, Hippocampus hippocampus, Hippocampus ramulosus, Mobula mobular, Caretta caretta, Dermochelys coriacea, Calonectris diomedea, Falco eleonorae, Hydrobates pelagicus, Larus audouinii, Phalacrocorax aristotelis, Phoenicopterus ruber, Puffinus yelkouan, Sterna albifrons, Balaenoptera physalus, Grampus griseus, Monachus monachus, Tursiops truncatus

Species whose exploitation is regulated  of the Annex III of the Protocol concerning specially protected areas and biological diversity in the Mediterranean  :  Hippospongia communis, Spongia agaricina, Spongia officinalis, Paracentrotus lividus, Homarus gammarus, Maja squinado, Palinurus elephas, Scyllarides latus, Scyllarus arctus, Scyllarus pigmaeus, Epinephelus marginatus, Sciaena umbra, Thunnus thynnus, Umbrina cirrosa, Xiphias gladius

Other significant species  :  Cymodocea nodosa, Zostera sp., Acetabularia acetabulum, Anadyomene sp., Halimeda tuna, Penicillus capitatus, Cystoseira sp., Dictyota sp., Padina pavonica, Sargassum sp., Lithophyllum byssoides, Peyssonnelia squamaria, Aplysina aerophoba, Axinella sp., Crambe crambe, Euspongia officinalis, Ircinia fasciculate, Ircinia sp., Ircinia variabilis fistulata, Oscarella lobularis, Sycon ciliatum, Actinia equina, Alcyonium acaule, Alicia mirabilis, Anemonia sulcata, Anemonia viridis, Aurelia aurita, Cerianthus membranacea, Cladocora caespitosa, Cribrinopsis crassa, Eunicella cavolinii, Eunicella singularis, Eunicella verrucosa, Paramuricea clavata, Parazoanthus axinellae, Antedon mediterranea , Arbaciella elegans, Asterina gibbosa, Brissus unicolor, Coscinasterias tenuispina, Echinaster sepositus, Echinus melo, Holothuria sp., Marthasterias glacialis, Ophioderma longicauda, Psammechinus microtuberculatus, Sphaerechinus granularis, Stylocidaris affinis, Myriapora truncata, Pentapora sp, Sertella beaniana, Smittina cervicornis, Aporrhais pespelecani, Arca noae, Astraea rugosa, Bolinus brandaris, Bolma rugosa, Cerithium scabridum, Cerithium vulgata, Clanculus corallinus, Discodoris atromaculata, Flabellina affinis, Haliotis lamellosa, Murex trunculus, Mytilus galloprovincialis, Octopus vulgaris, Ostrea edulis, Patella caerulea, Patella rustica, Sepia officinalis, Spondylus gaederopus, Balanus perforatus, Gnathophyllum elegans, Ligia italica, Maia verrucosa, Pachygrapsus marmoratus, Parapandalus narval, Stenopus spinosus, Acantholabrus palloni, Apogon imberbis, Balistes carolinensis, Boops boops, Chromis chromis, Conger conger, Coris julis, Coryphaena hippurus, Crenilabrus sp., Dasyatis sp, Dentex dentex, Dicentrarchus labrax, Diplodus annularis, Diplodus cervinus, Diplodus puntazzo, Diplodus puntazzo, Diplodus sargus, Diplodus sp., Diplodus vulgaris, Epinephelus aeneus, Epinephelus costae, Gobius cruentatus, Hippocampus guttulatus, Labrus bimaculatus, Labrus merula, Labrus viridis, Lapanella fasciata, Leucoraja melitensis, Lipophrys pavo, Lithognathus mormyrus , Lophius piscatorius, Mola mola, Mullus surmuletus, Muraena helena, Mycteroperca rubra, Myliobatis aquila, Oblada melanura, Pagellus acarne, Phycis phycis, Platichthys flesus (= Pleuronectes italicus), Polyprion americanus, Sarda sarda, Sargocentrum rubrum, Sarpa salpa, Scorpaena scrofa, Scorpaena sp, Seriola dumerilii, Serranus cabrilla, Serranus scriba, Sparus aurata, Sphyraena viridensis, Spicara maena, Symphodus tinca, Thalassoma pavo, Trachinus sp., Uranuscopus scaber, Xyrichthys novacula, Falco peregrinus, Protula tubularia , Sabella spallanzani, Serpula vermicularis, Halocynthia papillosa

Introduced species"  :  Caulerpa taxifolia, Asparagopsis armata