Principal species threatened or in danger  of the Annex II of the Protocol concerning specially protected areas and biological diversity in the Mediterranean  :  Posidonia oceanica, Zostera marina, Cystoseira amentacea (including var. stricta and var. spicata), Cystoseira zosteroides, Laminaria rodriguezii, Goniolithon byssoides, Lithophyllum lichenoides, Luria lurida (= Cypraea lurida), Patella ferruginea, Pinna nobilis, Cetorhinus maximus, Hippocampus ramulosus, Caretta caretta, Dermochelys coriacea, Calonectris diomedea, Hydrobates pelagicus, Larus audouinii, Phalacrocorax aristotelis, Balaenoptera physalus, Stenella coeruleoalba, Tursiops truncatus

Species whose exploitation is regulated  of the Annex III of the Protocol concerning specially protected areas and biological diversity in the Mediterranean  :  Corallium rubrum, Paracentrotus lividus, Homarus gammarus, Maja squinado, Palinurus elephas, Scyllarides latus, Epinephelus marginatus, Sciaena umbra, Umbrina cirrosa

Other significant species  :  Cymodocea nodosa, Acetabularia acetabulum, Halimeda tuna, Penicillus capitatus, Padina pavonica, Lithophyllum byssoides, Peyssonnelia squamaria, Aplysina aerophoba, Crambe crambe, Actinia equina, Anemonia sulcata, Cladocora caespitosa, Eunicella cavolinii, Paramuricea clavata, Parazoanthus axinellae, Antedon mediterranea , Echinaster sepositus, Echinus melo, Marthasterias glacialis, Psammechinus microtuberculatus, Sphaerechinus granularis, Myriapora truncata, Arca noae, Astraea rugosa, Bolinus brandaris, Flabellina affinis, Haliotis lamellosa, Murex trunculus, Mytilus galloprovincialis, Octopus vulgaris, Ostrea edulis, Patella caerulea, Patella rustica, Sepia officinalis, Balanus perforatus, Dardanus arrosor, Maia verrucosa, Pachygrapsus marmoratus, Apogon imberbis, Boops boops, Chromis chromis, Conger conger, Coris julis, Dentex dentex, Dicentrarchus labrax, Diplodus annularis, Diplodus puntazzo, Diplodus sargus, Diplodus vulgaris, Epinephelus costae, Lithognathus mormyrus , Lophius piscatorius, Mullus surmuletus, Muraena helena, Oblada melanura, Pagellus acarne, Phycis phycis, Raja clavata, Sarda sarda, Sarpa salpa, Scorpaena scrofa, Seriola dumerilii, Serranus cabrilla, Serranus scriba, Sparus aurata, Spicara maena, Symphodus tinca, Thalassoma pavo, Falco peregrinus, Larus michahellis, Serpula vermicularis, Halocynthia papillosa

Introduced species"  :  Caulerpa racemosa, Asparagopsis armata, Percnon gibbesi